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The impact of continuous subcutaneous insulin infusion on health‐related quality of life in children and adolescents with type 1 diabetes
Author(s) -
Júlíusson Pétur Benedikt,
Graue Marit,
WentzelLarsen Tore,
Søvik Oddmund
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1080/08035250600774114
Subject(s) - medicine , type 1 diabetes , ketoacidosis , diabetic ketoacidosis , overweight , diabetes mellitus , insulin pump , quality of life (healthcare) , insulin , metabolic control analysis , pediatrics , type 2 diabetes , obesity , endocrinology , nursing
Aim: To study the impact of continuous subcutaneous insulin infusion (CSII) therapy on health‐related quality of life in children and adolescents with type 1 diabetes. Methods: 31 children and adolescents with poorly regulated type 1 diabetes (mean HbA 1c 10.4%, SD 1.8), mean age 14.4 (1.5) y (range 9.7–17.1) and mean diabetes duration of 6.8 (3.2) y (range 1.3–14.6) were consecutively assigned to CSII therapy. Data for generic (CHQ‐CF87) and diabetes‐specific quality of life (DQOL) were obtained before initiating pump therapy and twice during 15 mo of treatment. HbA 1c , BMI and episodes of severe hypoglycaemia and ketoacidosis were recorded over 15 mo prior to and 15 mo during pump therapy. Results: Analysis showed improvements on the family activity scale ( p =0.041) and change in health score ( p =0.042) (CHQ‐CF87). Mean HbA 1c decreased from 10.4% (1.8) to 9.0% (0.9) after 3 mo, increasing to 9.6% (1.2) after 15 mo. The number of overweight and obese children increased from 4 and 2 before CSII, to 6 and 3 after 15 mo (IOTF criteria). There was a reduction in severe hypoglycaemia episodes from 43.8 to 5.2 per 100 patient years, but no change in ketoacidosis episodes. Conclusion: The degree of limitation experienced by families due to adolescents’ general health and well‐being was significantly reduced. Expected improvement in metabolic control and frequency of severe hypoglycaemia was observed.