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Analysis of Kawasaki disease showing elevated antibody titres of Yersinia pseudotuberculosis
Author(s) -
TAHARA MASAHIRO,
BABA KIYOSHI,
WAKI KENJI,
ARAKAKI YOSHIO
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1080/08035250600750080
Subject(s) - yersinia pseudotuberculosis , kawasaki disease , medicine , yersinia , antibody , incidence (geometry) , yersiniosis , yersinia enterocolitica , yersinia infections , gastroenterology , immunology , enterobacteriaceae , artery , bacteria , biology , escherichia coli , virulence , biochemistry , genetics , physics , gene , optics
Aim : To elucidate a clinical difference between patients with Kawasaki disease documented with Yersinia pseudotuberculosis infection and patients with Kawasaki disease without Yersinia pseudotuberculosis infection. Patients and methods: From January 1985 to July 2004, 452 patients were diagnosed with Kawasaki disease. Forty‐two patients had elevated antibody titres of Yersinia pseudotuberculosis and/or positive stool culture ( Yersinia ‐positive group). Three hundred and thirty patients had no elevated antibody titres ( Yersinia ‐negative group). We compared the clinical characteristics retrospectively. Results: The age of onset in the Yersinia ‐positive group (3.05±2.20 y) was significantly higher than that in the Yersinia ‐negative group (2.31±2.05 y) (p=0.03). The age‐adjusted statistical analysis demonstrated that the incidence of coronary artery lesions (dilatations plus aneurysms) in the Yersinia ‐positive group (22/42, 52.4%) was significantly higher than in the Yersinia ‐negative group (105/330, 31.8%) (p=0.001), and the incidence of additional administration of immunoglobulin in the Yersinia ‐positive group (13/36, 36.1%) was significantly higher than in the Yersinia ‐negative group (41/256, 16.0%) (p=0.004). Conclusion : Our data suggest that Yersinia pseudotuberculosis infection might play a role in the developing mechanism of poor response to therapy and the tendency to develop coronary artery lesions in Kawasaki disease patients.