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Genetic analyses of thiopurine methyltransferase polymorphisms in Greenlandic and Danish populations
Author(s) -
TOFT NINA,
NYGAARD ULRIKKA,
GREGERS JANNIE,
SCHMIEGELOW KJELD
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1080/08035250600743788
Subject(s) - thiopurine methyltransferase , allele , danish , medicine , population , allele frequency , methyltransferase , genetics , biology , azathioprine , gene , linguistics , philosophy , disease , environmental health , methylation
Aim : To determine the frequency of thiopurine methyltransferase (TPMT) low‐activity alleles in the Greenlandic and Danish populations. Methods : 142 Greenlandic individuals and 200 Danish blood donors were screened for the TPMT G460A and A719G low‐activity alleles. Results: Thiopurine methyltransferase low‐activity alleles were significantly higher in the Greenlandic compared to the Danish population, being 8.1% (95% CI 4.9–11.3) and 3.5% (95% CI 1.7–5.3) (p<0.01), respectively. Except for one Danish patient with an A719G allele (TPMT*3C), all the aberrant alleles were compound G460A and A719G alleles (TPMT*3A). Conclusion : In the Danish population, the incidence of thiopurine methyltransferase low‐activity alleles was found to be similar to other Caucasian populations previously described. In contrast, the Greenlandic population showed a significantly higher frequency of thiopurine methyltransferase low‐activity alleles.