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Glutamate in current paediatric amino acid solutions is not toxic
Author(s) -
Pohlandt Frank
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1080/08035250600681681
Subject(s) - medicine , glutamate receptor , parenteral nutrition , bolus (digestion) , intensive care medicine , amino acid , anesthesia , biochemistry , chemistry , receptor
Aim: To discuss the viewpoint article “How much glutamate is toxic in paediatric parenteral nutrition?” Acta Paediatr 2005;94;16–9. Conclusion: There is no doubt that glutamate used at high bolus doses in animal experiments would permanently damage brain cells. However, these effects should not be extrapolated to the condition of parenteral nutrition of newborn infants when much smaller amounts of glutamate are infused constantly during 24 h. Clinical studies proving the maintenance of plasma glutamate concentrations within the reference range during parenteral nutrition were not considered. The authors have alarmed neonatologists with arguments without substance.