Premium
Effect of indomethacin on closure of ductus arteriosus in very‐low‐birthweight neonates 1
Author(s) -
Godambe Sunit,
Newby Brandi,
Shah Vibhuti,
Shah Prakesh S.
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1080/08035250600615150
Subject(s) - medicine , ductus arteriosus , neonatal intensive care unit , pulmonary surfactant , pediatrics , intensive care unit , intraventricular hemorrhage , anesthesia , tertiary care , gestational age , pregnancy , physics , genetics , biology , thermodynamics
Aim : To identify factors related to indomethacin non‐responsiveness for patent ductus arteriosus (PDA) closure in very‐low‐birthweight (VLBW) neonates. Methods : A chart review of 107 VLBW neonates with a clinical diagnosis of PDA who received indomethacin, admitted to a tertiary neonatal intensive care unit in Toronto, Canada, was conducted (study period November 2001 to October 2003). Positive responders were those with no clinical evidence of PDA for 72 h after indomethacin. Results : Response to the first course of indomethacin was 75%, and to the second course 67% among initial responders. Higher CRIB score (OR 1.15, 95% CI 1.02–1.31) and early surfactant administration (OR 3.74, 95% CI 1.04–13.47) were associated with non‐responsiveness to indomethacin. Conclusion : Indomethacin is effective for PDA closure. The response rate diminished with subsequent courses. Early surfactant and severity of illness at admission were associated with non‐responsiveness to indomethacin.