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Electrogastrography in children and adolescents with type 1 diabetes: Weak correlation with metabolic control parameters
Author(s) -
ToporowskaKowalska Ewa,
WasowskaKrólikowska Krystyna,
Szadkowska Agnieszka,
Bodalski Jerzy
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1080/08035250600589025
Subject(s) - postprandial , medicine , type 1 diabetes , gastroenterology , diabetes mellitus , endocrinology , metabolic control analysis
Aim : To evaluate gastric myoelectrical activity with respect to duration and metabolic control of type 1 diabetes mellitus (T1DM). Methods : 172 children and adolescents with T1DM (mean 14.4±3.7 y), divided into subgroups depending on diabetes duration (<5 and > 5 y), and 35 healthy controls (mean 13.93±3.59 y) were examined. All subjects underwent electrogastrography (EGG) performed after overnight fasting. In subjects with T1DM, haemoglobin A1c (HbA1c) and blood glucose levels during EGG records were measured. Results : 15.69% of T1DM patients and 91.42% of the controls fulfilled normal EGG criteria ( p < 0.001). T1DM subjects had a lower percentage of fasting normogastria (34.56±27.35% vs 69.84±18.16%, p = 0.0001) and higher bradygastria (51.97±30.24% vs 19.11±15.01%, p = 0.0001) compared to controls. In diabetic patients, an increase in postprandial normogastria (60.37±23.96% vs 76.68±12.38, p < 0.05) and a decrease in bradygastria percentage (25.67±21.01% vs 9.58±7.13%, p < 0.05) was observed. In children with disease < 5 y, diabetes duration correlated with power ratio ( r = ‐ 0.27, p = 0.01), postprandial normogastria ( r = ‐ 0.24, p = 0.03) and tachygastria ( r = 0.25, p = 0.02). Weak correlations between EGG parameters and glucose ( p reprandial dominant frequency r = ‐ 0.19, p < 0.05; postprandial normogastria r = 0.23, p < 0.01) and HbA1c levels ( p reprandial bradygastria r = 0.19, postprandial dominant power r = 0.23; p < 0.05) were observed. Conclusion : Gastric myoelectrical rhythm derangement is present in a large proportion of young diabetic patients. Bradygastria is the most prominent EGG abnormality. Weak correlation was found between EGG parameters and diabetes metabolic control.