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Vasopressin in catecholamine‐resistant septic and cardiogenic shock in very‐low‐birthweight infants
Author(s) -
Meyer Sascha,
Löffler Günther,
Polcher Thorsten,
Gottschling Sven,
Gortner Ludwig
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1080/08035250500538973
Subject(s) - medicine , cardiogenic shock , vasopressin , septic shock , shock (circulatory) , blood pressure , catecholamine , refractory (planetary science) , anesthesia , cardiology , sepsis , physics , astrobiology , myocardial infarction
Aim : To evaluate vasopressin as a rescue therapy in catecholamine‐refractory septic and cardiogenic shock in very‐low‐birthweight (VLBW) infants. Methods : Prospective assessment of vasopressin therapy in three VLBW infants with catecholamine‐refractory septic shock (24+.6 wk, 600 g) and cardiogenic shock (26+.1 wk, 890 g; 26+.1 wk, 880 g) at a university hospital. Results : Adequate systemic arterial blood pressure could only be restored after vasopressin administration as a continuous infusion over a 36‐h period in the preterm suffering from septic shock; in the two neonates with cardiogenic shock, only a transient stabilization in mean arterial pressure was observed, which did not impact on the poor prognosis. Conclusion : Although vasopressin appears to be a suitable rescue therapy in catecholamine‐resistant septic shock in VLBW infants, further evaluation in controlled clinical trials is warranted.