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End‐tidal carbon monoxide measurements in infant respiratory distress syndrome
Author(s) -
Krediet Tannette G.,
Cirkel Geert A.,
Vreman Hendrik J.,
Wong Ronald J.,
Stevenson David K.,
Groenendaal Floris,
Egberts Johannes,
Bel Frank
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1080/08035250500537017
Subject(s) - medicine , respiratory distress , respiratory disease , respiratory system , lung , gastroenterology , anesthesia
Background: RDS involving inflammatory and oxidative processes may lead to increased production of carbon monoxide (CO). Aim: The relationship between end‐tidal CO, corrected for inhaled CO (ETCOc), and RDS severity was investigated in preterm infants as well as the value of early ETCOc measurements to predict chronic lung disease. Methods: 78 infants (30 no RDS, 32 moderate RDS, 16 severe RDS) were included. ETCOc was measured using the CO‐Stat™ End Tidal Breath Analyzer. Results: ETCOc was significantly higher in RDS compared to no RDS during the first week ( p <0.05). Severity of RDS was the most significant independent variable in a stepwise regression model related to ETCOc (F‐test: 18.17). Negative predictive value of early (within first 12 h of life) ETCOc measurement (<2.5 ppm) for development of chronic lung disease was excellent (100%). Conclusion: During severe RDS, inflammation may contribute to increased lipid peroxidation leading to increased local CO production in the lung, indicated by increased ETCOc. Early ETCOc determinations may be helpful to exclude occurrence of chronic lung disease.