Open AccessElectrolyte handling in the isolated perfused rat kidney: demonstration of vasopressin V2-receptor-dependent calcium reabsorption
Author(s) -
Krister Bamberg,
Lena William-Olsson,
Ulrika Johansson,
Anders Arner,
Judith HartleibGeschwindner,
Johan Sällström
Publication year - 2020
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.1080/03009734.2020.1804496
Subject(s) - reabsorption , endocrinology , renal sodium reabsorption , medicine , vasopressin , amiloride , arginine vasopressin receptor 2 , calcium , vasopressin receptor , renal physiology , kidney , urine osmolality , sodium , chemistry , receptor , antagonist , organic chemistry
The most profound effect of vasopressin on the kidney is to increase water reabsorption through V 2 -receptor (V 2 R) stimulation, but there are also data suggesting effects on calcium transport. To address this issue, we have established an isolated perfused kidney model with accurate pressure control, to directly study the effects of V 2 R stimulation on kidney function, isolated from systemic effects.