Open AccessDistinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy
Author(s) -
Mehrnaz Haghi,
Raheleh Masoudi,
Seyed Morteza Najibi
Publication year - 2020
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.1080/03009734.2020.1785063
Subject(s) - tauopathy , autophagy , atg8 , cathepsin d , drosophila melanogaster , tau protein , microbiology and biotechnology , amyloid precursor protein , biology , gene , medicine , neurodegeneration , genetics , pathology , alzheimer's disease , disease , biochemistry , apoptosis , enzyme
Alzheimer's disease (AD) is one the most common types of dementia. Plaques of amyloid beta and neurofibrillary tangles of tau are two major hallmarks of AD. Metabolism of these two proteins, in part, depends on autophagy pathways. Autophagy dysfunction and protein aggregation in AD may be involved in a vicious circle. The aim of this study was to investigate whether tau or amyloid beta 42 (Aβ42) could affect expression of autophagy genes, and whether they exert their effects in the same way or not.