Open AccessLong-term health of children conceived after assisted reproductive technology
Author(s) -
Christina Bergh,
UllaBritt Wennerholm
Publication year - 2020
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.1080/03009734.2020.1729904
Subject(s) - medicine , assisted reproductive technology , pediatrics , narrative review , disease , type 1 diabetes , cerebral palsy , asthma , psychiatry , diabetes mellitus , pregnancy , infertility , intensive care medicine , immunology , genetics , biology , endocrinology
The aim of this narrative review is to summarize the present knowledge on long-term outcome of children born after assisted reproductive technologies (ART). The main outcomes covered are neurodevelopment including cerebral palsy, cognitive development, attention deficit hyperactivity disorder and autism spectrum disease, growth, cardiovascular function, diabetes type 1, asthma, malignancies, and reproductive health. Results have mainly been obtained from systematic reviews/meta-analyses and large registry studies. It has been shown that children born after ART, when restricted to singletons, have a similar outcome for many health conditions as their spontaneously conceived peers. For some outcomes, particularly cardiovascular function and diabetes, studies show some higher risk for ART singletons or subgroup of ART singletons. The fast introduction of new ART techniques emphasizes the importance of continuous surveillance of children born after ART.