Open AccessOxidative stress but not endothelial dysfunction exists in non‐obese, young group of patients with polycystic ovary syndrome
Author(s) -
KUŞÇU NACI KEMAL,
VAR AHMET
Publication year - 2009
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340902859315
Subject(s) - polycystic ovary , endothelial dysfunction , medicine , oxidative stress , body mass index , von willebrand factor , endocrinology , superoxide dismutase , insulin resistance , nitric oxide , obesity , platelet
Objective . To determine if oxidative stress and endothelial dysfunction exist at the same time in a young, non‐obese group of patients with polycystic ovary syndrome (PCOS). Design . Cross‐sectional study. Setting . Celal Bayar University, School of Medicine, Manisa, Turkey. Sample . Thirty‐one young, non‐obese patients with PCOS and 23 age‐ and body mass index‐matched controls. Methods . Following clinical and biochemical diagnosis, malonyldialdehyde (MDA), superoxide dismutase (SOD), von Willebrand Factor (vWF), and nitric oxide (NO) levels of patients and controls were measured and compared. Main outcome measures . To find out oxidative stress and endothelial dysfunction parameters. Results . MDA (0.12±0.03 vs 0.10±0.03, p = 0.01) and SOD (8.0±0.7 vs 7.28±0.8, p = 0.001) levels were significantly higher in PCOS group while there was no difference in vWF (527.2±280.1 vs 568.1±276.8, p >0.05) and NO levels (169.9±47.4 vs 168.9±80, p >0.05). When the results of the PCOS patients were divided into two subgroups in terms of insulin resistance (IR– and IR +), the IR– subgroup had significantly higher MDA levels compared to the control (0.125±0.03 vs 0.101±0.03, p = 0.03). Though IR+ group also had higher MDA than the control group, it did not reach to a significant level (0.117±0.05 vs 0.101±0.03, p >0.05). Both IR– and IR+ groups had significantly higher SOD levels compared with control group (7.99±0.7 vs 7.28±0.8, p = 0.009 and 8.22±0.8 vs 7.28±0.8, p = 0.03, respectively). vWF and NO levels were not different among these three groups ( p >0.05). Conclusions . Oxidative stress is prominent while endothelial dysfunction does not exist in young, non‐obese patients with PCOS.