Open AccessReduced bone mineral density in adult women diagnosed with menstrual disorders during adolescence
Author(s) -
WIKSTENALMSTRÖMER MARIANNE,
HIRSCHBERG ANGELICA LINDÉN,
HAGENFELDT KERSTIN
Publication year - 2009
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340902846080
Subject(s) - medicine , osteopenia , amenorrhea , osteoporosis , bone mineral , polycystic ovary , body mass index , bone density , pediatrics , menstrual cycle , gynecology , physical therapy , obstetrics , obesity , pregnancy , hormone , insulin resistance , biology , genetics
Objective. To evaluate the long‐term effects on bone mineral density (BMD) in women diagnosed with menstrual disorders in their adolescence. Design . Prospective follow‐up study six years after the initial investigation. Setting . A youth clinic that is part of the school health system in Stockholm. Population . Eighty‐seven women diagnosed with secondary amenorrhea or oligomenorrhea in adolescence. Methods . Subjects underwent gynecological examination, evaluation of eating behavior and physical activity. Whole body Dual Energy X‐ray Absorptiometry was used for measurement of BMD. Main outcome measures . BMD. Results . The overall frequency of osteopenia/osteoporosis was 52%, and three girls had osteoporosis. Women with previous secondary amenorrhea had significantly lower BMD in the pelvis and lumbar spine than those with previous oligomenorrhea. The strongest predictor of low BMD was a restrictive eating disorder in adolescence and the most important counteraction was high physical activity at follow‐up and a body mass index (BMI) ≥ 22. Persistent menstrual dysfunction at follow‐up was associated with polycystic ovary syndrome and lower frequency of osteopenia. Conclusions. This clinical follow‐up study has demonstrated a high frequency of osteopenia in women diagnosed with menstrual disorders in adolescence. Previous anorectic behavior was the strongest negative predictor of BMD. It is important to pay attention to an underlying eating disorder in young women with menstrual dysfunction in order to promote bone health.