Open AccessEfficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro fertilization
Author(s) -
KUMBAK BANU,
KAHRAMAN SEMRA
Publication year - 2009
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340902835919
Subject(s) - metformin , medicine , polycystic ovary , ovarian hyperstimulation syndrome , in vitro fertilisation , pregnancy rate , gynecology , ovulation induction , pregnancy , body mass index , retrospective cohort study , population , ovulation , endocrinology , diabetes mellitus , obesity , insulin resistance , hormone , biology , genetics , environmental health
Objective . To evaluate the effect of metformin addition during ovarian hyperstimulation on cycle parameters and outcome of in vitro fertilization (IVF) treatment in polycystic ovary syndrome (PCOS) patients with a body mass index (BMI) <28 kg/m 2 . Design . Retrospective review of patients’ records. Setting . Istanbul Memorial Hospital Assisted Reproductive Treatment Unit. Population . A total of 339 non‐obese PCOS patients undergoing IVF were evaluated according to the supplementation of metformin. Methods . Cycle parameters and IVF outcomes of 220 patients given metformin were compared to those of 119 patients treated without metformin. Main outcome measures . Implantation and pregnancy rates. Results . Metformin co‐treatment led to significantly lower peak E2 levels (3,481 pg/ml vs. 4,192 pg/ml; p <0.0001). However, gonadotropin consumption, stimulation duration, numbers of total and mature oocytes retrieved, fertilization rate, and ratio of grade I embryos developed were similar in both groups. In the metformin administered group, significantly higher implantation (25% vs. 18%; p = 0.003) and pregnancy rates (58% vs. 45%; p = 0.04) were achieved. Abortion and moderate–severe ovarian hyperstimulation syndrome rates were found to be similar in both groups. Conclusions . Although metformin use was especially and strongly recommended in obese PCOS cases, its supplementation during IVF in PCOS patients with a BMI <28 kg/m 2 was observed to be beneficial and efficacious.