Open AccessSecond trimester neutrophil gelatinase‐associated lipocalin as a potential prediagnostic marker of preeclampsia
Author(s) -
D'ANNA ROSARIO,
BAVIERA GIOVANNI,
GIORDANO DOMENICO,
TODARELLO GIOVANNA,
CORRADO FRANCESCO,
BUEMI MICHELE
Publication year - 2008
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340802464463
Subject(s) - medicine , interquartile range , preeclampsia , lipocalin , neutrophil gelatinase associated lipocalin , immunoassay , pathophysiology , case control study , proteinuria , endocrinology , biomarker , pregnancy , gastroenterology , immunology , antibody , kidney , biology , genetics , biochemistry
Neutrophil gelatinase‐associated lipocalin (NGAL) concentrations, a product of neutrophils, were investigated in normal and preeclamptic pregnancies. Prospectively collected data and late second trimester (24–26 weeks) serum samples from 48 women who subsequently developed preeclampsia (PE) and 96 control women with uncomplicated pregnancies were compared. Serum NGAL values, as determined by quantitative sandwich enzyme immunoassay, were significantly increased in the preeclamptic compared to the control women: 76.9 ng/ml (interquartile range 39.7–96.5) versus 16.0 ng/ml (interquartile range 11.2–24.4) ( p <0.001), and were positively correlated to blood pressure and proteinuria, showing a high sensitivity (75%) and specificity (94.5%). The results suggest that serum NGAL might be involved in the pathophysiology of PE and could be a marker for this syndrome.