Open AccessMMP‐2, TIMP‐1, E‐cadherin, and β‐catenin expression in endometrial serous carcinoma compared with low‐grade endometrial endometrioid carcinoma and proliferative endometrium
Author(s) -
SHACOLEVY RUTHY,
SHARABI SHALOM,
PIURA BENJAMIN,
SIONVARDY NETTA
Publication year - 2008
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340802253775
Subject(s) - medicine , endometrium , carcinoma , serous fluid , cadherin , catenin , matrix metalloproteinase , endometrial cancer , cancer research , oncology , gynecology , cancer , cell , signal transduction , biology , biochemistry , wnt signaling pathway , genetics
Abstract Objective. To investigate the expression of MMP‐2, TIMP‐1, E‐cadherin and β‐catenin in endometrial serous carcinoma (ESC), low‐grade endometrial endometrioid carcinoma (EEC), and proliferative endometrium. Methods. We performed an immunohistochemical study on 14 cases of ESC, 15 cases of low‐grade EEC, and 10 cases of proliferative endometrium. Results. Compared with low‐grade EEC, ESC showed significantly increased MMP‐2 and TIMP‐1 expression, as well as decreased membranous β‐catenin staining. E‐cadherin expression was significantly lower in ESC and EEC as compared with proliferative endometrium. Conclusions. We suggest that MMP‐2 and TIMP‐1 expression and loss of β‐catenin have a role in the pathogenesis and progression of ESC. Decreased E‐cadherin may have an important role in the development of both ESC and EEC. Furthermore, the dissimilarities in MMP‐2, TIMP‐1, E‐cadherin and β‐catenin expressions in ESC compared with EEC may be responsible, along with other factors, for their different biological behavior.