Open AccessFetal lipoprotein changes in pre‐eclampsia
Author(s) -
CATARINO CRISTINA,
REBELO IRENE,
BELO LUÍS,
ROCHAPEREIRA PETRONILA,
ROCHA SUSANA,
BAYER CASTRO ELISABETH,
PATRÍCIO BELMIRO,
QUINTANILHA ALEXANDRE,
SANTOSSILVA ALICE
Publication year - 2008
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340802085318
Subject(s) - medicine , apolipoprotein b , umbilical cord , preeclampsia , fetus , lipid profile , pregnancy , cholesterol , endocrinology , eclampsia , lipoprotein , low density lipoprotein , obstetrics , immunology , biology , genetics
Objective . To evaluate the impact of maternal lipid changes upon the fetus in pre‐eclampsia (PE) by evaluating lipid profile simultaneously in maternal and umbilical cord blood (UCB). Design . Case‐control study performed on healthy and pre‐eclamptic pregnant women and their neonates. Setting . The Department of Obstetrics and Gynecology, Hospital S. Joao and Faculty of Pharmacy, Porto, Portugal. Samples . Forty‐two healthy pregnancies and 46 pregnancies complicated with PE. Methods . Total cholesterol (TChol), HDL‐cholesterol (HDLc), LDL‐cholesterol (LDLc) and triglycerides (TG) levels were determined using enzymatic methods. Apolipoprotein (apo) A‐I, apoB and lipoprotein (a) [Lp(a)] values were measured by immunoturbidimetry. Main outcome measures . Fetal and maternal plasma levels of TChol, HDLc, LDLc, TG, apoA‐I, apoB and Lp(a). Results . Pre‐eclamptic women presented significantly higher values for TChol, LDLc, HDLc, TG, apoA‐I and apoB compared to normal pregnant women. In the UCB from pre‐eclamptic pregnancies, we observed significantly lower values for HDLc and apoA‐I, and significantly higher TG concentrations and LDLc/HDLc ratio when compared to normal cases. A positive correlation was observed between maternal TG levels and proteinuria, a marker of PE severity ( r =0.40, p <0.01). Conclusions . Our data suggest that pre‐eclamptic pregnancy is associated with an enhanced hyperlipidemia, which seems to have a negative impact on fetal lipid profile, as reflected by a higher atherogenic LDLc/HDLc ratio and higher TG levels. These children, born of women with PE, may deserve a closer clinical follow‐up later in life.