Open AccessInterleukin‐10 −1082 G/A promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1,616 pregnant women
Author(s) -
STONEK FELIX,
METZENBAUER MARTIN,
HAFNER ERICH,
PHILIPP KARL,
TEMPFER CLEMENS
Publication year - 2008
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340801995657
Subject(s) - medicine , prospective cohort study , pregnancy , obstetrics , gynecology , cohort , cohort study , genetics , biology
Objective. To investigate the frequency of the interleukin‐10 (IL‐10)−1082 G/A single nucleotide polymorphism in women with intrauterine fetal death (IUFD), pre‐eclampsia (PE), preterm delivery (PD), and small for gestational age (SGA) infants. Methods. In a prospective cohort study, DNA from 1,616 consecutive pregnant women was analyzed for IL‐10 −1082 G/A by polymerase chain reaction. Women who developed at least one of the predefined pregnancy complications were used as cases and compared to women without pregnancy complications. Results. Of 1,616 women, 254 (15.7%) developed at least one pregnancy complication. IL‐10 −1082 G/A allele frequencies (G: 233/508 [45.9%] and A: 275/508 [54.1%] versus G: 1,143/2,724 [42.0%] and A: 1,581/2,724 [58.0%], respectively; p = 0.10; OR 0.85; 95% CI 0.69–1.04) and genotype distributions (A/A+G/A: 201/254 [79.1%] and G/G 53/254 [20.9%] versus A/A+G/A: 1,125/1,362 [82.6%] and G/G 237/1,362 [17.4%], respectively, p = 0.19; OR 0.79; 95% CI 0.54–1.15) were not significantly different between cases and controls. We observed no statistically significant difference in IL‐10 −1082 G/A genotype distribution comparing controls and women with IUFD, PE, PD <37 weeks gestation, and SGA infants (<10th percentile). Conclusion. IL‐10 −1082 G/A polymorphism is not a genetic marker for identifying women at increased risk of common pregnancy complications.