Open AccessPrognostic factors for recurrence in patients with FIGO stage I and II, intermediate or high risk endometrial cancer
Author(s) -
ZUSTERZEEL P.L.M.,
BEKKERS R.L.M.,
HENDRIKS J.C.M.,
NEESHAM D.N.,
ROME R.M.,
QUINN M.A.
Publication year - 2008
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340701876163
Subject(s) - medicine , endometrial cancer , stage (stratigraphy) , gynecology , oncology , cancer , obstetrics , paleontology , biology
Background . The aim of this study was to determine predictors for loco‐regional or distant recurrence of disease in a subgroup of intermediate or high risk stage I and II endometrial cancer. Methods . A retrospective analysis of 295 patients with histopathological stage I and II, intermediate or high risk endometrial cancer is reported. The following factors were studied: stage, grade, age, histologic diagnosis, lymphadenectomy, lymphovascular space invasion, and adjuvant radiotherapy. The Log‐Rank test was used for statistical analyses and the Kaplan–Meyer method was used for time‐to‐event analysis. Multivariate analysis was also performed. Results . Thirty‐four (11.5%) patients developed a recurrence; 20 (59%) developed loco‐regional recurrence, and 14 (41%) developed distant recurrence. In 20 women (59%), recurrence appeared within 3 years of surgery, and the actuarial survival at 3 years after recurrence was 29%. Multivariate analysis showed that for recurrence, age >60 years was a significant unfavourable prognostic factor ( p < 0.05). Conclusions . We found low rates of recurrence in patients with early stage intermediate or high risk endometrial cancer. Only age was identified as an independent significant predictor for recurrence.