Open AccessVNTR I/I genotype of insulin gene is associated with the increase of follicle number independent from polycystic ovary syndrome
Author(s) -
HALLER KADRI,
LAISK TRIIN,
PETERS MAIRE,
TALVING ELLE,
KARITS PEETER,
KARRO HELLE,
UIBO RAIVO,
SALUMETS ANDRES
Publication year - 2007
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340701322085
Subject(s) - polycystic ovary , infertility , insulin resistance , medicine , minisatellite , endocrinology , genotype , menstrual cycle , follicle , follicle stimulating hormone , female infertility , hormone , insulin , allele , biology , luteinizing hormone , genetics , gene , pregnancy , microsatellite
Background. Polycystic ovary syndrome (PCOS) is accompanied by selective insulin resistance and enhanced ovarian steroidogenic effects of insulin. We analysed the minisatellite variations of the insulin gene ( INS VNTR) with regard to the clinical features of PCOS. Methods. Retrospective, adjusted association study. Infertile patients with PCOS ( n = 30) and tubal factor ( n = 75) were screened for anthropometrical, clinical and ovarian morphology parameters, as well as hormonal values. INS VNTR was genotyped by its surrogate marker at −23 Hph I locus. Results. INS VNTR genotype distribution was similar in PCOS and tubal infertility group. The mean ovarian follicle number was higher in VNTR I/I individuals compared to VNTR I/III and III/III individuals (adjusted OR = 1.28, p = 0.03), independent from the cause of infertility, the age, the follicle stimulating hormone level on day 3–5 of menstrual cycle, BMI and the previous surgical ovarian tissue removal. In addition, higher level of the luteinising hormone in VNTR I/I individuals was associated with the increase in follicle number. Conclusions. We suggest that INS VNTR genotypes are not associated with PCOS in general, but could have a certain influence on the phenotypic spectrum of the syndrome.