Open AccessSerum levels of activin A and inhibin A are not related to the increased susceptibility to pre‐eclampsia in type I diabetic pregnancies
Author(s) -
EKBOM PIA,
DAMM PETER,
ANDERSSON ANNAMARIA,
SKAKKEBÆK NIELS ERIK,
FELDTRASMUSSEN ULLA,
MATHIESEN ELISABETH R.
Publication year - 2006
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1080/00016340500345311
Subject(s) - medicine , eclampsia , gestation , endocrinology , gestational diabetes , pregnancy , diabetes mellitus , body mass index , type 2 diabetes , obstetrics , biology , genetics
Background . Activin A and inhibin A have been found to be elevated in women without diabetes subsequently developing pre‐eclampsia. The aim was to investigate whether activin A and inhibin A in serum were elevated in type I diabetic women after developing pre‐eclampsia and, if so, were they clinically useful as predictors of pre‐eclampsia. Methods . In a prospective study, maternal serum was analyzed for activin A and inhibin A in 115 women with type 1 diabetes at 10, 14, 22, 28, and 33 weeks of gestation. Results . Fourteen women (12%) developed pre‐eclampsia (26–37 weeks of gestation) and 101 did not. The two groups were comparable regarding age, body mass index, and diabetes duration. There was no difference between serum concentrations of activin A and inhibin A in women developing pre‐eclampsia and women who did not at any gestational period. Conclusions . Serum concentrations of activin A and inhibin A could not predict pre‐eclampsia in type I diabetes.