Open AccessHerpes Virus-like DNA (HHV-8) in Immunosuppressive Therapy-related, HIV-related and Classical Kaposi's Sarcoma in Norwegian Patients
Author(s) -
Petter Jensen,
Yao Qi Huang,
Jian Jun Li,
O. P. F. Clausen,
A. E. Friedman-Kien
Publication year - 1998
Publication title -
acta dermato-venereologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.982
H-Index - 83
eISSN - 1651-2057
pISSN - 0001-5555
DOI - 10.1080/000155598441549
Subject(s) - sarcoma , virology , herpes virus , virus , kaposi's sarcoma , polymerase chain reaction , pathogenesis , medicine , immunology , biology , human herpesvirus , pathology , gene , genetics
The recently discovered human herpes virus 8 (Kaposi's sarcoma-associated herpes virus) has been implicated in the pathogenesis of Kaposi's sarcoma. Using polymerase chain reaction we detected DNA sequences of this herpes virus in 11 of 14 biopsy specimens from Kaposi's sarcoma in Norwegian patients, including the immunosuppressive therapy-related type (3 of 3), the HIV-related type (4 of 5), and the classical type (4 of 6). The results support the hypothesis of a role for human herpes virus 8 in all types of Kaposi's sarcoma independent of geographical area.