Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV | Zendy

Enrico Garaci | Zendy; Maria Cristina Caroleo | Zendy; Luigi Aloe | Zendy; Stefano Aquaro | Zendy; Mauro Piacentini | Zendy; Nicola Costa | Zendy; Alessandra Amendola | Zendy; Alessandra Micera | Zendy; R Caliò | Zendy; Carlo Federico Perno | Zendy; Rita LeviMontalcini | Zendy

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Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV

Author(s) -

Enrico Garaci,

Maria Cristina Caroleo,

Luigi Aloe,

Stefano Aquaro,

Mauro Piacentini,

Nicola Costa,

Alessandra Amendola,

Alessandra Micera,

R Caliò,

Carlo Federico Perno,

Rita LeviMontalcini

Publication year - 1999

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.96.24.14013

Subject(s) - nerve growth factor , autocrine signalling , tropomyosin receptor kinase a , receptor , low affinity nerve growth factor receptor , growth factor , biology , neurotrophin , in vitro , microbiology and biotechnology , biochemistry

Nerve growth factor (NGF) is a neurotrophin with the ability to exert specific effects on cells of the immune system. Human monocytes/macrophages (M/M) infected in vitro with HIV type 1 (HIV-1) are able to produce substantial levels of NGF that are associated with enhanced expression of the high-affinity NGF receptor (p140 trkA) on the M/M surface. Treatment of HIV-infected human M/M with anti-NGF Ab blocking the biological activity of NGF leads to a marked decrease of the expression of p140 trkA high-affinity receptor, a concomitant increased expression of p75(NTR) low-affinity receptor for NGF, and the occurrence of apoptotic death of M/M. Taken together, these findings suggest a role for NGF as an autocrine survival factor that rescues human M/M from the cytopathic effect caused by HIV infection.

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