Open AccessAn X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.
Author(s) -
Carla Tribioli,
Sara Droetto,
Silvia Bione,
Gianni Cesareni,
Maria Rosaria Torrisi,
Lavinia Vittoria Lotti,
Luisa Lanfrancone,
Daniela Toniolo,
PierGiuseppe Pelicci
Publication year - 1996
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.93.2.695
Subject(s) - biology , gene , ras superfamily , microbiology and biotechnology , gtp binding protein regulators , genetics , signal transduction , homologous chromosome , g protein , gtp' , biochemistry , enzyme
An increasingly large number of proteins involved in signal transduction have been identified in recent years and shown to control different steps of cell survival, proliferation, and differentiation. Among the genes recently identified at the tip of the long arm of the human X chromosome, a novel gene, C1, encodes a protein that appears to represent a newly discovered member of the group of signaling proteins involved in regulation of the small GTP binding proteins of the ras superfamily. The protein encoded by C1, p115, is synthesized predominantly in cells of hematopoietic origin. It is characterized by two regions of similarity to motifs present in known proteins: GAP and SH3 homologous regions. Its localization in a narrow cytoplasmic region just below the plasma membrane and its inhibitory effect on stress fiber organization indicate that p115 may down regulate rho-like GTPases in hematopoietic cells.