Limitations of Darwinian selection in a finite population. | Zendy

Makoto Kimura | Zendy

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Limitations of Darwinian selection in a finite population.

Author(s) -

Makoto Kimura

Publication year - 1995

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.92.6.2343

Subject(s) - selection (genetic algorithm) , population , effective population size , biology , genetics , evolutionary biology , mutation rate , demography , computer science , genetic variation , gene , artificial intelligence , sociology

In a finite population, the rate at which favorable mutations at several loci can evolve simultaneously is limited by the reproductive capacity of the species and the effective population number. The number of such loci is given by n < - (Ne/2) ln(1-LT), in which Ne is the effective population number and LT is the "substitution load" (roughly, the reproductive excess available for positive selection). If LT = 0.1, as seems reasonable for large mammals, n < 0.05Ne.

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