Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor. | Zendy

Raffaella Calligaris | Zendy; Stefania Bottardi | Zendy; Susanna Cogoi | Zendy; Isabel Apezteguia | Zendy; Claudio Santoro | Zendy

Open Access

Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.

Author(s) -

Raffaella Calligaris,

Stefania Bottardi,

Susanna Cogoi,

Isabel Apezteguia,

Claudio Santoro

Publication year - 1995

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.92.25.11598

Subject(s) - transactivation , zinc finger , transcription factor , biology , gata transcription factor , gata2 , start codon , gata4 , haematopoiesis , microbiology and biotechnology , translation (biology) , messenger rna , genetics , gene , gene expression , stem cell , promoter

GATA-1 is a zinc-finger transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. In human and murine erythroid cells a previously undescribed 40-kDa protein is detected with GATA-1-specific antibodies. We show that the 40-kDa GATA-1 (GATA-1s) is produced by the use of an internal AUG initiation codon in the GATA-1 transcript. The GATA-1 proteins share identical binding activity and form heterodimers in erythroleukemic cells but differ in their transactivation potential and in their expression in developing mouse embryos.

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