Effect of erythrocyte membrane on extracellular development of the erythrocytic cycle of Plasmodium falciparum. | Zendy

Jonathan Williams | Zendy; G.S. Gill | Zendy; W. Trager | Zendy

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Effect of erythrocyte membrane on extracellular development of the erythrocytic cycle of Plasmodium falciparum.

Author(s) -

Jonathan Williams,

G.S. Gill,

W. Trager

Publication year - 1995

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.92.2.566

Subject(s) - axenic , erythrocyte membrane , biology , plasmodium falciparum , red blood cell , microbiology and biotechnology , in vitro , biochemistry , membrane , immunology , malaria , bacteria , genetics

We have earlier reported conditions that support the axenic development in vitro of a complete asexual erythrocytic cycle of Plasmodium falciparum. Up to 30% of merozoites showed initial differentiation into trophic forms (rings) viable at 14 hr. However, only approximately 1% of the merozoites would develop further into trophozoites and early schizonts viable at 36 hr. In efforts to increase the number of late stage parasites, we have now found a significant favorable effect of the addition of erythrocyte ghosts. Doubling the quantity of erythrocyte membrane in the erythrocyte sonicate medium resulted in approximate doubling of the number of trophozoites and early schizonts. These results indicate that components of the erythrocyte membrane are essential for the complete development of the erythrocytic cycle.

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