Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning. | Zendy

Catherine Heurteaux | Zendy; Inger Lauritzen | Zendy; Catherine Widmann | Zendy; Michel Lazdunski | Zendy

Open Access

Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning.

Author(s) -

Catherine Heurteaux,

Inger Lauritzen,

Catherine Widmann,

Michel Lazdunski

Publication year - 1995

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.92.10.4666

Subject(s) - adenosine , glutamate receptor , receptor , adenosine receptor , adenosine a1 receptor , stimulation , pharmacology , adenosine a3 receptor , purinergic signalling , adenosine a2b receptor , chemistry , biology , neuroscience , microbiology and biotechnology , agonist , biochemistry

Preconditioning with sublethal ischemia protects against neuronal damage after subsequent lethal ischemic insults in hippocampal neurons. A pharmacological approach using agonists and antagonists at the adenosine A1 receptor as well as openers and blockers of ATP-sensitive K+ channels has been combined with an analysis of neuronal death and gene expression of subunits of glutamate and gamma-aminobutyric acid receptors, HSP70, c-fos, c-jun, and growth factors. It indicates that the mechanism of ischemic tolerance involves a cascade of events including liberation of adenosine, stimulation of adenosine A1 receptors, and, via these receptors, opening of sulfonylurea-sensitive ATP-sensitive K+ channels.

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