Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion. | Zendy

Jacqueline R. Wyatt | Zendy; Timothy A. Vickers | Zendy; Joseph L. Roberson | Zendy; Robert W. Buckheit | Zendy; Thomas Klimkait | Zendy; Elizabeth L. DeBaets | Zendy; Peter W. Davis | Zendy; Bernard Rayner | Zendy; J.L. IMBACH | Zendy; David J. Ecker | Zendy

Open Access

Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion.

Author(s) -

Jacqueline R. Wyatt,

Timothy A. Vickers,

Joseph L. Roberson,

Robert W. Buckheit,

Thomas Klimkait,

Elizabeth L. DeBaets,

Peter W. Davis,

Bernard Rayner,

J.L. IMBACH,

David J. Ecker

Publication year - 1994

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.91.4.1356

Subject(s) - guanosine , tetramer , oligonucleotide , biology , in vitro , virology , v3 loop , virus , microbiology and biotechnology , biochemistry , peptide sequence , gene , enzyme

The phosphorothioate oligonucleotide T2G4T2 wasidentified as an inhibitor of HIV infection in vitro by combinatorial screeningof a library of phosphorothioate oligonucleotides that contained all possibleoctanucleotide sequences. The oligonucleotide forms a parallel-strandedtetrameric guanosine-quartet structure. Tetramer formation and thephosphorothioate backbone are essential for antiviral activity. The tetramerbinds to the human immunodeficiency virus envelope protein gp120 at the V3 loopand inhibits both cell-to-cell and virus-to-cell infection.

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