Open AccessPhysical association between nonhomologous chromosomes precedes distributive disjunction in yeast.
Author(s) -
Josef Loidl,
Harry Scherthan,
David B. Kaback
Publication year - 1994
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.91.1.331
Subject(s) - homologous chromosome , genetics , meiosis , homologous recombination , biology , distributive property , saccharomyces cerevisiae , genetic recombination , chromosomal crossover , non allelic homologous recombination , recombination , flp frt recombination , non homologous end joining , yeast , gene , mathematics , pure mathematics
During meiosis homologous chromosomes normally pair, undergo reciprocal recombination, and then segregate from each other. Distributive disjunction is the meiotic segregation that is observed in the absence of homologous recombination and can occur for both nonrecombinant homologous chromosomes and completely nonhomologous chromosomes. While the mechanism of distributive disjunction is not known, several models have been presented that either involve or are completely independent of interactions between the segregating chromosomes. In this report, we demonstrate that distributive disjunction in Saccharomyces cerevisiae is preceded by an interaction between nonhomologous chromosomes.