Inverted repeat structure of the Sry locus in mice. | Zendy

John Gubbay | Zendy; Nigel Vivian | Zendy; Androulla Economou | Zendy; Dean A. Jackson | Zendy; Peter N. Goodfellow | Zendy; Robin LovellBadge | Zendy

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Inverted repeat structure of the Sry locus in mice.

Author(s) -

John Gubbay,

Nigel Vivian,

Androulla Economou,

Dean A. Jackson,

Peter N. Goodfellow,

Robin LovellBadge

Publication year - 1992

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.89.17.7953

Subject(s) - testis determining factor , y chromosome , locus (genetics) , biology , genetics , open reading frame , microbiology and biotechnology , chromosome , gene , peptide sequence

The testis-determining gene Sry is located on the short arm of the mouse Y chromosome in a region known to have undergone duplications and rearrangements in comparison with the equivalent portion of the human Y chromosome. Detailed analysis of the Sry genomic locus reveals a further difference in that the mouse Sry open reading frame lies within 2.8 kilobases of unique sequence at the center of a large inverted repeat. This repeat, which is found in both Mus musculus musculus and Mus musculus domesticus Y chromosomes, is not present at the human SRY locus. Recombination involving the repeat region may have led to an 11-kilobase deletion, precisely excising Sry in a line of XY female mice.

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