Error filtration, interference, and the human linkage map. | Zendy

Denis C. Shields | Zendy; Andrew Collins | Zendy; Kenneth H. Buetow | Zendy; Newton E. Morton | Zendy

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Error filtration, interference, and the human linkage map.

Author(s) -

Denis C. Shields,

Andrew Collins,

Kenneth H. Buetow,

Newton E. Morton

Publication year - 1991

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.88.15.6501

Subject(s) - pairwise comparison , linkage (software) , interference (communication) , filter (signal processing) , statistics , algorithm , computer science , mathematics , biology , genetics , computer vision , telecommunications , channel (broadcasting) , gene

Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.

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