Open AccessError filtration, interference, and the human linkage map.
Author(s) -
Denis C. Shields,
Andrew J. Collins,
Kenneth H. Buetow,
N. E. Morton
Publication year - 1991
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.88.15.6501
Subject(s) - pairwise comparison , linkage (software) , interference (communication) , filter (signal processing) , statistics , algorithm , computer science , mathematics , biology , genetics , computer vision , telecommunications , channel (broadcasting) , gene
Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.