Open AccessSuppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells.
Author(s) -
Tze-Sing Huang,
Sheng-Chung Lee,
JenKun Lin
Publication year - 1991
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.88.12.5292
Subject(s) - tumor promotion , curcumin , phorbol , signal transduction , fibroblast , tetradecanoylphorbol acetate , in vitro , chemistry , microbiology and biotechnology , biology , biochemistry , cancer research , protein kinase c , gene , carcinogenesis
Curcumin, a dietary pigment responsible for the yellow color of curry, is a potent inhibitor of tumor promotion by phorbol esters. Functional activation of transcriptional factor c-Jun/AP-1 is believed to play an important role in signal transduction of phorbol 12-myristate 13-acetate-induced tumor promotion. Suppression of the c-Jun/AP-1 activation by curcumin is observed in mouse fibroblast cells. In vitro experiments indicate that inhibition of c-Jun/AP-1 binding to its cognate motif by curcumin may be responsible for the inhibition of c-Jun/AP-1-mediated gene expression. These findings show that the effect of curcumin on phorbol 12-myristate 13-acetate-induced inflammation/tumor promotion could be studied at the molecular level.