Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. | Zendy

Joseph Fargnoli | Zendy; Takahiro Kunisada | Zendy; Albert J. Fornace | Zendy; Edward L. Schneider | Zendy; Nikki J. Holbrook | Zendy

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Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats.

Author(s) -

Joseph Fargnoli,

Takahiro Kunisada,

Albert J. Fornace,

Edward L. Schneider,

Nikki J. Holbrook

Publication year - 1990

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.87.2.846

Subject(s) - hsp70 , heat shock protein , messenger rna , fibroblast , gene expression , lung , microbiology and biotechnology , shock (circulatory) , protein expression , biology , protein biosynthesis , gene , medicine , andrology , endocrinology , chemistry , biochemistry , in vitro

The effect of aging on the induction of heat shock protein 70 (HSP70)-encoding gene expression by elevated temperatures was studied in cultures of lung- or skin-derived fibroblasts from young (5 mo) and old (24 mo) male Wistar rats. Although the kinetics of the heat shock response were found to be similar in the two age groups, we observed lower levels of induction of HSP70 mRNA and HSP70 protein in confluent primary lung and skin fibroblast cultures derived from aged animals. Additional experiments with freshly excised lung tissue showed a similar age-related decline in the heat-induced expression of HSP70.

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