Open AccessCharacterization of ROS1 cDNA from a human glioblastoma cell line.
Author(s) -
Carmen Birchmeier,
Kathy E. O’Neill,
Michael Riggs,
Michael Wigler
Publication year - 1990
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.87.12.4799
Subject(s) - receptor tyrosine kinase , complementary dna , ros1 , biology , transmembrane protein , transmembrane domain , tyrosine kinase , extracellular , cdna library , microbiology and biotechnology , kinase , gene , genetics , signal transduction , receptor , adenocarcinoma , cancer
We have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8.3 kilobases long, has the potential to encode a transmembrane tyrosine-specific protein kinase with a predicted molecular mass of 259 kDa. The putative extracellular domain of ROS1 is homologous to the extracellular domain of the sevenless gene product from Drosophila. No comparable similarities in the extracellular domains were found between ROS1 and other receptor-type tyrosine kinases. Together, ROS1 and sevenless gene products define a distinct subclass of transmembrane tyrosine kinases.