Open AccessVariable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.
Author(s) -
Makio Iwashima,
Adrienne Green,
Mark M. Davis,
Yuehhsiu Chien
Publication year - 1988
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.85.21.8161
Subject(s) - delta , t cell receptor , biology , coding region , microbiology and biotechnology , exon , gene , genetics , t cell , physics , immune system , astronomy
A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.