Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region. | Zendy

Makio Iwashima | Zendy; Adèle C. Green | Zendy; Mark M. Davis | Zendy; Yueh-hsiu Chien | Zendy

Open Access

Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.

Author(s) -

Makio Iwashima,

Adèle C. Green,

Mark M. Davis,

Yueh-hsiu Chien

Publication year - 1988

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.85.21.8161

Subject(s) - delta , t cell receptor , biology , coding region , microbiology and biotechnology , exon , gene , genetics , t cell , physics , immune system , astronomy

A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.

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