Alteration of lipid-phase behavior in multiple sclerosis myelin revealed by wide-angle x-ray diffraction. | Zendy

Loo Sar Chia | Zendy; J.E. Thompson | Zendy; M A Moscarello | Zendy

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Alteration of lipid-phase behavior in multiple sclerosis myelin revealed by wide-angle x-ray diffraction.

Author(s) -

Loo Sar Chia,

J.E. Thompson,

M A Moscarello

Publication year - 1984

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.81.6.1871

Subject(s) - myelin , phospholipid , chemistry , multiple sclerosis , bilayer , proteolipid protein 1 , lipid bilayer , myelin basic protein , liposome , biophysics , biochemistry , crystallography , biology , membrane , endocrinology , immunology , central nervous system

Wide-angle x-ray diffraction studies revealed that the lipid-phase transition temperature of multiple sclerosis (MS) myelin was about 20 degrees C lower than that of normal myelin, indicating differences in the physical organization of the bilayer. The transition temperature of liposomes prepared from total lipid extracts of normal myelin was 12 degrees C lower than that for corresponding intact myelin, demonstrating that the protein of normal myelin had a substantial ordering effect on the lipid bilayer. The transition temperature for liposomes of MS myelin lipid was essentially similar to that for isolated MS myelin. Because the protein/phospholipid ratio was higher in MS myelin, and no difference in degree of fatty acid saturation was observed, the inability of MS myelin protein to organize the lipid reflects a qualitative difference in the proteins.

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