Open AccessMonoclonal antibodies against trophectoderm-specific markers during mouse blastocyst formation.
Author(s) -
Philippe Brûlet,
Charles Babinet,
Rolf Kemler,
François Jacob
Publication year - 1980
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.77.7.4113
Subject(s) - inner cell mass , blastocyst , biology , monoclonal antibody , microbiology and biotechnology , antibody , embryo , immunology , embryogenesis
Two-dimensional gel electrophoresis has allowed the detection of proteins characteristic of inner cell mass and trophectoderm in mouse blastocyst. Certain of the proteins characterizing trophectoderm copurify with intermediate filaments from trophectoderm and a trophoblastoma cell line. A monoclonal antibody prepared against proteins of these intermediate filaments labels a filament network in trophectoderm but not in inner cell mass cells.