Open AccessThe RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast.
Author(s) -
Robert E. Malone,
Rochelle Easton Esposito
Publication year - 1980
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.77.1.503
Subject(s) - mitotic crossover , mating of yeast , homothallism , mating type , rad52 , recombination , flp frt recombination , genetics , biology , gene conversion , homologous recombination , saccharomyces cerevisiae , mating , yeast , genetic recombination , gene , rad51
The rad52-1 mutation prevents homothallic mating type interconversion and reduces mitotic recombination in yeast. It has been previously reported that rad52-1 abolishes meiotic recombination. These data suggest either that a generalized recombination function(s) is required for mating type switching or that generalized recombination and specific homothallic functions are jointly controlled by the RAD52 gene. The rad52-1 mutation affects the interconversion of the two yeast mating types (a and alpha) differently, suggesting that the interconversion process is not equivalent for both mating types. This type of asymmetry is not predicted by current models of homothallic switching.