Junctional modulation in mouse embryonal carcinoma cells by Fab fragments of rabbit anti-embryonal carcinoma cell serum. | Zendy

Irène Dunia | Zendy; Jean–François Nicolas | Zendy; H Jakob | Zendy; E. L. Benedetti | Zendy; F Jacob | Zendy

Open Access

Junctional modulation in mouse embryonal carcinoma cells by Fab fragments of rabbit anti-embryonal carcinoma cell serum.

Author(s) -

Irène Dunia,

Jean–François Nicolas,

H Jakob,

E. L. Benedetti,

F Jacob

Publication year - 1979

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.76.7.3387

Subject(s) - embryonal carcinoma , gap junction , tight junction , microbiology and biotechnology , cell culture , biology , cell , chemistry , carcinoma , cell junction , cellular differentiation , biochemistry , intracellular , genetics , gene

Mouse embryonal carcinoma PCC4 cells are connected by extensive gap and tight junctions. When the cells are incubated in a medium containing Fab fragments against embryonal carcinoma F9 cells, they round up and a process of junctional removal is initiated. In particular, gap junctions are internalized and after 30 hr of incubation with the anti-F9 Fab fragments both tight and gap junctions are no longer present at the cell surface; however, the cells are still in contact by means of small attachment sites.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research