Chromosomal assignment of the mouse kappa light chain genes. | Zendy

Daniel Swan | Zendy; Peter D’Eustachio | Zendy; Leslie A. Leinwand | Zendy; Jonathan G. Seidman | Zendy; D Keithley | Zendy; F.H. Ruddle | Zendy

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Chromosomal assignment of the mouse kappa light chain genes.

Author(s) -

Daniel Swan,

Peter D’Eustachio,

Leslie A. Leinwand,

Jonathan G. Seidman,

D Keithley,

F.H. Ruddle

Publication year - 1979

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.76.6.2735

Subject(s) - gene , biology , genetics , microbiology and biotechnology , chromosome , immunoglobulin light chain , somatic cell , kappa , nucleic acid , nucleic acid thermodynamics , dna , antibody , rna , linguistics , philosophy

Mouse-hamster somatic cell hybrids containing a variable number of mouse chromosomes have been used in experiments to determine which mouse chromosome carries the immunoglobulin kappa light chain genes. It has been shown by nucleic acid hybridization that the kappa constant gene and the genes for at least one variable region subgroup are on mouse chromosome 6. This somatic cell genetic mapping procedure appears to be general and can be applied to any expressed or silent gene for which an appropriate nucleic acid probe exists.

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