Open AccessX-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma.
Author(s) -
Ralph R. Weichselbaum,
John Nove,
John B. Little
Publication year - 1978
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.75.8.3962
Subject(s) - retinoblastoma , ploidy , cancer research , biology , genetics , dna , pathology , medicine , gene
Fibroblasts derived from patients with hereditary retinoblastoma appear to be more sensitive to the lethal effects of x-rays than do fibroblasts from patients with sporadic retinoblastoma or normal controls. A defect in DNA repair is postulated to account for the high incidence of second tumors in these patients. Retinoblastoma appears to be an interesting model for the study of genetic susceptibility to the development of spontaneous or radiation-induced tumors.