Identification of 5,8-oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid. | Zendy

Joseph L. Napoli | Zendy; Anne M. McCormick | Zendy; Heinrich K. Schnoes | Zendy; Hector F. DeLuca | Zendy

Open Access

Identification of 5,8-oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid.

Author(s) -

Joseph L. Napoli,

Anne M. McCormick,

Heinrich K. Schnoes,

Hector F. DeLuca

Publication year - 1978

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.75.6.2603

Subject(s) - retinoic acid , chromatography , vitamin , chemistry , mass spectrometry , retinoid , biochemistry , gene

A retinoid was isolated by a multistep procedure from the small intestines of vitamin A-deficient rats given a single dose of retinoic acid. The compound, designated 8II, was pure, as demonstrated by four high-pressure liquid chromatographic procedures. It was positively identified as 5,8-oxyretinoic acid by ultraviolet spectrophotometry, mass spectrometry, and spectral and chromatographic comparison to known compounds. It is probable that 5,8-oxyretinoic acid was produced from 5,6-epoxyretinoic acid under the acidic conditions used in the isolation. It is highly probable, therefore, that the natural product is 5,6-epoxyretinoic acid.

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