Open AccessIonic factors in release of 45Ca2+ from chicken cerebral tissue by electromagnetic fields.
Author(s) -
S.M. Bawin,
W. R. Adey,
Irene Sabbot
Publication year - 1978
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.75.12.6314
Subject(s) - extracellular , bicarbonate , calcium , biophysics , stimulation , efflux , chemistry , ionic bonding , stimulus (psychology) , lanthanum , nuclear magnetic resonance , biochemistry , inorganic chemistry , ion , endocrinology , biology , physics , psychology , organic chemistry , psychotherapist
Electrical stimulation with radiofrequency fields amplitude-modulated at brain wave frequencies increased 45Ca2+ efflux from isolated chicken cerebral tissue. The response was not sensitive to variations of the calcium concentration (0-4.16 mM) in the bathing solution but was enhanced by addition of H+ (0.108 mM HCl) and inhibited in the absence of normal bicarbonate levels (2.4 mM). Addition of lanthanum to the bicarbonate-free solution restored electrical responsiveness, but the stimulus decreased instead of increasing 45Ca2+ efflux. It is suggested that low-frequency, weak, extracellular electric gradients may be transduced in a specific class of extracellular negative binding sites normally occupied by Ca2+ and susceptible to competitive H+ binding.