Cholinergic metabolism and synapse formation by a rat nerve cell line. | Zendy

D Schubert | Zendy; Steve Heinemann | Zendy; Yoshiaki Kidokoro | Zendy

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Cholinergic metabolism and synapse formation by a rat nerve cell line.

Author(s) -

D Schubert,

Steve Heinemann,

Yoshiaki Kidokoro

Publication year - 1977

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.74.6.2579

Subject(s) - choline acetyltransferase , acetylcholine , cholinergic , cell culture , synapse , choline , microbiology and biotechnology , biology , adenosine , nerve growth factor , neuromuscular junction , endocrinology , cholinergic neuron , chemistry , medicine , biochemistry , neuroscience , receptor , genetics

The PC12 clone of a rat pheochromocytoma is able to synthesize acetylcholine. The amount of acetylcholine synthesized, and the specific activity of choline O-acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6), varies as a function of the culture growth curve and is dependent on cell density. The specific activity of choline acetyltransferase is increased by nerve growth factor, growth-conditioned medium from a variety of cell types, and adenosine 3':5'-monophosphate. Finally, the PC12 cell line is able to form cholinergic synapses with a clonal cell line of skeletal muscle origin.

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