Open AccessC-type virus particle formation in erythroblastic islands in spleens of C3Hf mice injected with erythropoietin.
Author(s) -
Dorothy Feldman
Publication year - 1976
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.73.10.3710
Subject(s) - erythropoiesis , erythropoietin , spleen , biology , virus , budding , virology , microbiology and biotechnology , immunology , medicine , endocrinology , anemia
Previous studies suggested a possible association between C-type virus particle formation and erythropoiesis. In this experiment, normal C3Hf mice were injected with erythropoietin in order to increase the rate of erythropoiesis. Sections of spleen from these animals revealed extensive areas of erythroblasts. C-type particles, budding from erythroblasts, were often observed in such areas of spleen from every mouse injected with erythropoietin. In contrast, in sections of spleen from control mice, zones of erythropoiesis were limited, and only a few scattered C-type virus particles were observed in some of the animals examined.