Catabolite modulator factor: a possible mediator of catabolite repression in bacteria. | Zendy

A Ullmann | Zendy; F Tillier | Zendy; Jacques Monod | Zendy

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Catabolite modulator factor: a possible mediator of catabolite repression in bacteria.

Author(s) -

A Ullmann,

F Tillier,

Jacques Monod

Publication year - 1976

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.73.10.3476

Subject(s) - catabolite repression , fed batch culture , biochemistry , psychological repression , lac operon , chemistry , escherichia coli , operon , biology , microbiology and biotechnology , fermentation , gene , gene expression , mutant

Water soluble extracts of Escherichia coli cells have been found to exert an extremely strong repressive effect upon the expression of catabolite sensitive operons. The compound responsible for this activity has been partially purified and proves to be of low molecular weight and heat stable. The effect of this compound, hereafter designated as catabolite modulator factor, is only partially antagonized by adenosine 3':5'-cyclic monophosphate. The possible role of catabolite modulator factor in the physiological regulation of catabolite repression is discussed.

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