Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins. | Zendy

Steven J. Burden | Zendy; H. Criss Hartzell | Zendy; Doju Yoshikami | Zendy

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Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins.

Author(s) -

Steven J. Burden,

H. Criss Hartzell,

Doju Yoshikami

Publication year - 1975

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.72.8.3245

Subject(s) - acetylcholine receptor , biology , acetylcholine , alpha (finance) , snake venom , receptor , venom , squamata , neurotoxin , phylogenetic tree , neuroscience , zoology , endocrinology , biochemistry , medicine , construct validity , nursing , gene , patient satisfaction

Phylogenetic differences in acetylcholine receptors from skeletal neuromuscular synapses of various species of snakes and lizards have been investigated, using the snake venom alpha-neurotoxins alpha-atratoxin (cobrotoxin) and alpha-bungarotoxin. The acetylcholine receptors of the phylogenetically primitive lizards, like those from all other vertebrates previously tested, are blocked by these alpha-neurotoxins. In contrast, receptors from snakes and advanced lizards are insensitive to one or both of the toxins. It is suggested that toxin-resistant acetylcholine receptors appeared early in the evolution of Squamata and preceded the appearance of alpha-neurotoxins.

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