A Genetic Marker in the Variable Region of Light Chains of Mouse Immunoglobulins | Zendy

Gerald M. Edelman | Zendy; Paul Gottlieb | Zendy

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A Genetic Marker in the Variable Region of Light Chains of Mouse Immunoglobulins

Author(s) -

Gerald M. Edelman,

Paul Gottlieb

Publication year - 1970

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.67.3.1192

Subject(s) - immunoglobulin light chain , mendelian inheritance , genetics , cystine , biology , amino acid , peptide sequence , antibody , microbiology and biotechnology , chemistry , gene , biochemistry , enzyme , cysteine

A genetic variation was observed upon autoradiographic comparison of tryptic peptide maps of14 C-labeled normal light chains from 17 different inbred strains of mice. The difference was found in strains AKR/J, C58/J, and RF/J. Chemical analyses showed that the differences were in a region of the amino acid sequence in the neighborhood of half-cystine I of the variable region of the light chain. Breeding experiments showed that the difference segregated in a classical Mendelian fashion.

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