Open AccessOXYTOCIN AND NEUROHYPOPHYSEAL PEPTIDES: SPECTRAL ASSIGNMENT AND CONFORMATIONAL ANALYSIS BY 220 MHz NUCLEAR MAGNETIC RESONANCE
Author(s) -
L. F. Johnson,
Irving L. Schwartz,
Roderich Walter
Publication year - 1969
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.64.4.1269
Subject(s) - homonuclear molecule , oxytocin , chemistry , nuclear magnetic resonance , resonance (particle physics) , proton magnetic resonance , spectral line , chemical shift , physics , biology , endocrinology , molecule , atomic physics , organic chemistry , astronomy
Magnetic resonance peaks have been assigned to individual protons of the constituent amino acids in the neurohypophyseal hormone, oxytocin, and in related peptides. The assignments were made possible by operation at 220 MHz with the use of variable temperature studies, proton homonuclear spin-decoupling, and comparison of spectra of oxytocin analogs. Some of the observed chemical shifts, and NH-CHα coupling constants were studied in relation to the conformation of the hormone.